Doctors have been trying to get their patients to consistently take medications since the advent of medicine. Even Hippocrates described how some of his patients would feign compliance to his treatment plans. It may seem like a simple concept, yet achieving compliance has been elusive in modern medicine despite iterations of potential solutions. Complex factors make up the barriers for medical compliance, and it is unlikely that there is one catch-all solution. Using advancements in mobile health to address these issues could potentially decrease the morbidity and mortality of noncompliance.